Cancer cells needMTH1...
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REFERENCIAS
1. Gad, H.; Koolmeister, T.; Jemth, A.-‐S.; Eshtad, S.; Jacques, S. A.; Ström, C. E.; Svensson, L. M.;
Schultz, N.; Lundbäck, T.; Einarsdottir, B. O.; Saleh, A.; Göktürk, C.; Baranczewski, P.;
Svensson, R.; Berntsson, R. P.-‐A.; Gustafsson, R.; Strömberg, K.; Sanjiv, K.; Jacques-‐
Cordonnier,M.-‐C.; Desroses,M.; Gustavsson, A.-‐L.; Olofsson, R.; Johansson, F.; Homan, E. J.;
Loseva, O.; Bräutigam, L.; Johansson, L.; Höglund, A.; Hagenkort, A.; Pham, T.; Altun, M.;
Gaugaz, F. Z.; Vikingsson, S.; Evers, B.; Henriksson, M.; Vallin, K. S. A.; Wallner, O. A.;
Hammarström, L. G. J.; Wiita, E.; Almlöf, I.; Kalderén, C.; Axelsson, H.; Djureinovic, T.;
Carreras Puigvert, J.; Häggblad, M.; Jeppsson, F.; Martens, U.; Lundin, C.; Lundgren, B.;
Granelli, I.; Jenmalm Jensen, A.; Artursson, P.; Nilsson, J. A.; Stenmark, P.; Scobie, M.;
Berglund, U. W.; Helleday, T.; (2014) “MTH1 inhibition eradicates cancer by preventing
sanitationof thedNTPpool”;Nature, doi: 10.1038/nature13181.
2. Kilian V. M. Huber, Eidarus Salah, Branka Radic, Manuela Gridling, Jonathan M. Elkins,
Alexey Stukalov, Ann-‐Sofie Jemth, CamillaGöktürk, Kumar Sanjiv, Kia Strömberg, Therese
Pham, Ulrika Warpman Berglund, Jacques Colinge, Keiryn L. Bennett, Joanna I. Loizou,
Thomas Helleday, Stefan Knapp & Giulio Superti-‐Furga; (2014) “Stereospecific targeting
ofMTH1by (S)-‐crizotinibas ananticancer strategy”;Nature, doi:10.1038/nature13194.
3. Streib,M.; Kräling, K.; Richter, K.; Xie, X.; Steuber, H.;Meggers, E.; (2014) “AnOrganometallic
Inhibitor for the Human Repair Enzyme 7,8-‐Dihydro-‐8-‐oxoguanosine Triphosphatase”,
Angew. Chem. Int. Ed., 53, 305-‐309.
4. Halliwell, B.; Gutteridge, J. M. C.; (1999) “Free Radicals in Biology and Medicine”, 3rd
Edition, OxfordUniversityPress.
5. Cheng, K. C.; Cahill, D. S.; Kasai, H.; Nishimura, S.; Loeb, L. A.; (1992) “8-‐Hydroxyguanine, an
Abundant Form of Oxidative DNA Damage Causes G→T and C→A substitutions”, J. Biol.
Chem., 267, 166-‐172.
6. Nakabeppu, Y.; Kajitani, K.; Sakamoto, K.; Yamaguchi, H.; Tsuchimoto, D.; (2006) “MTH1, an
oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of
oxidizedpurinenucleotides”, DNARepair (Amst), 5, 761-‐772.
7. Svensson, L. M.; Jemth, A.-‐S.; Desroses, M.; Loseva, O.; Helleday, T.; Högbom, M.; Stenmark,
P.; (2011) “Crystal structure of human MTH1 and the 8-‐oxo-‐dGMP product complex”,
FEBSLett., 585, 2617-‐2621.
8. Nakabeppu, Y.; Tsuchimoto, D.; Furuichi,M.; Sakumi, K.; (2004) “Thedefensemechanisms in
mammalian cells against oxidative damage in nucleic acids and their involvement in the
suppressionofmutagenesis andcell death”, FreeRadic. Res. 2004, 38, 423-‐429(Review).
9. Nakabeppu, Y.; Tsuchimoto, D.; Ichinoe, A.; Ohno, M.; Ide, Y.; Hirano, S.; Yoshimura, D.;
Tominaga, Y.; Furuichi, M.; Sakumi, K.; (2004) “Biological significance of the defense
mechanisms against oxidative damage innucleic acids causedby reactive oxygen species:
frommitochondria tonuclei.”Ann. N. Y. Acad. Sci. 1011,101-‐111.
10. Nakabeppu, Y.; Tsuchimoto, D.; Yamaguchi, H.; Sakumi, K.; (2007) “Oxidative damage in
nucleicacids andParkinson'sdisease.”, J. Neurosci. Res., 85, 919-‐934. (Review).
