Protein tyrosine phosphatase deficiency…
681
6. REFERENCES
1. Rumack, B. H. Acetaminophen misconceptions. Hepatology 40,10-15 (2004).
2. Thomas, S. H. L. Paracetamol (acetaminophen) poisoning. Pharmacol. Ther. 60, 91–120
(1993).
3. Litovitz, T. L.; Klein-Schwartz, W.; Rodgers, G. C.; Cobaugh, D. J.; Youniss, J.; Omslaer, J. C.;
May, M. E.; Woolf, A. D.; Benson, B. E. 2001 annual report of the American Association of
Poison Control Centers Toxic Exposure Surveillance System. Am. J. Emerg. Med. 20, 391–
452 (2002).
4. Lee, W. M. Acetaminophen toxicity: changing perceptions on a social /medical issue.
Hepatology 46, 966-970 (2007).
5. Kaplowitz, N. Acetaminophen hepatoxicity: what do we know, what don't we know, and
what do we do next? Hepatology 40, 3-26 (2004).
6. Prescott, L. F. Hepatotoxicity of mild analgesics. Br. J. Clin. Pharmacol. 2, 373-379 (1980).
7. Lee, W. M. Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks
of hepatic failure. Hepatology 40, 6–9 (2004).
8. Cohen, S. D.; Khairallah, E.A. Selective protein arylation and acetaminophen
induced hepatotoxicity. Drug Metab. Rev. 29, 59-77 (1997).
9. James, L. P.; Mayeux, P. R.; Hinson, J. A. Acetaminophen-induced hepatotoxicity. Drug Metab.
Dispos. 31, 1499–1506 (2003).
10. Jaeschke, H.; Bajt, M. L. Intracellular signaling mechanisms of acetaminophen induced liver
cell death. Toxicol. Sci. 89, 31–41 (2006).
11. Bessems, J. G,; Vermeulen, N. P. Paracetamol (acetaminophen)-induced toxicity: molecular
and biochemical mechanisms, analogues and protective approaches. Crit. Rev. Toxicol. 31,
55–138 (2001).
12. Nelson, S. G.; Wan, Z.; Stan, M. A. S (N)2 ring opening of beta-lactones: an alternative to
catalytic asymmetric conjugate additions. J. Org. Chem. 67, 4680–4683 (2002).
13. Vermeulen N. P. E.; Bessems J. G. M.; Vandestraat R. Molecular aspects of paracetamol-
induced hepatotoxicity and its mechanism-based prevention. Drug Metab. Rev. 24, 367–
407 (1992).
14. Dong, H.; Haining, R. L.; Thummel, K. E.; Rettie, A. E.; Nelson, S. D. Involvement of human
cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metab. Dispos. 28,
1397-1400 (2000).
15. Snawder, J. E.; Roe, A. L.; Benson, R. W.; Roberts, D. W. Loss of CYP2E1 and CYP1A2 activity
as a function of acetaminophen dose: relation to toxicity. Biochem. Biophys. Res. Commun.
203, 532-539 (1994).
16. Ghosh, A.; Sil, P. C. Protection of acetaminophen induced mitochondrial dysfunctions and
hepatic necrosis via Akt-NF-KB pathway: role of a novel plant protein. Chem. Biol. Interact.
177, 96-106 (2009).
17. Mitchell, J. R,; Jollow, D. J.; Potter, W. Z.; Gillette, J. R.; Brodie, B. B. Acetaminophen-induced
hepatic necrosis. IV. Protective role of glutathione. J. Pharmacol. Exp. Ther. 187, 211-217
(1973).
18. Reid, A.; Kurten, R.; McCullough, S.; Brock, R.; Hinson, J. Mechanisms of acetaminophen-
induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition
in freshly isolated mouse hepatocytes. J. Pharmacol.Exp. Ther. 312, 509–516 (2005).
19. Tonks, N. K.; Neel, B. G. Combinatorial control of the specificity of protein tyrosine
phosphatases. Curr. Opin. Cell Biol. 13,182-195 (2001).
20. Frangioni, J. V.; Beahm, P. H.; Shifrin, V.; Jost, C. A.; Neel, B. G. The nontransmembrane
tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid
C-terminal sequence. Cell 68, 545-560 (1992).
21. Flint, A. J.; Tiganis, T.; Barford, D.; Tonks, N. K. Development of "substrate-trapping"
mutants to identify physiological substrates of protein tyrosine phosphatases. Proc. Natl.
Acad. Sci. 94, 1680-1685 (1997).
22. Haj, F. G.; Markova, B.; Klaman, L. D.; Bohmer, F. D.; Neel, B. G. Regulation of receptor
tyrosine kinase signaling by protein tyrosine phosphatase-1B. J. Biol. Chem. 278, 739-744
(2003).
23. Salmeen, A.; Andersen, J. N.; Myers, M. P.; Tonks, N. K.; Barford, D. Molecular basis for
recognition and dephosphorylation of the activation segment of the insulin receptor by
protein tyrosine phosphatase 1B. Mol. Cell 6, 1401-1412 (2000).
