JoséMaríaRojo, Pilar Portolés
124
MS
Multiplesclerosis
mTOR
MechanisticTarget ofRapamycin
mTORC1 ComplexofmTORcontainingRaptor
mTORC2 ComplexofmTORcontainingRictor
NFAT
Nuclear factorof activatedT-‐cells
NF-‐
κ
B
Nuclear factor
κ
-‐light-‐chain-‐enhancerof activatedBcells
NK
Natural killer lymphocytes
S6K
p70S6kinase
PD-‐1
Programmeddeath-‐1, CD279
PDGF
Platelet-‐derivedgrowth factor
PDK1
Phosphoinositide-‐dependent kinase1
PGE2
ProstaglandinE2
PH
Pleckstrinhomologydomain
PIKK
PI3K-‐likeproteinkinases
PI3K
Phosphoinositide-‐3kinases (PI3Ks)
PKC
θ
Proteinkinase
θ
PKB
ProteinkinaseB
PLC
γ
PhospholipaseC
γ
PROPPIN
β
-‐propeller thatbindphosphoinositidespecies
PTEN
PhosphataseandTensinHomologue
PtdInsP Phosphorylated inositol lipids
PX
Phoxhomologydomain
RHEB
Rashomologueenriched inbrain
SH2
Srchomologyregion2domain
SH3
Srchomologyregion3domain
SHP-‐1
SH2domain-‐containing Inositol Phosphatase-‐1
SHP-‐2
SH2domain-‐containing Inositol Phosphatase-‐2
SGK1
Serum-‐ andglucocorticoid-‐induciblekinase (SGK)1
SLE
SystemicLupusErythematosus
TCR
Tcell receptor, antigenreceptorofT lymphocytes
Tfh
FollicularhelperTcells
TNF
Tumornecrosis factor
TSC1, TSC2 Tuberous sclerosis complexproteins1and2
Treg
CD4
+
regulatoryT lymphocytes
TRIM Tcell receptor (TCR)-‐interactingmolecule
WDrepeat WD40repeat,
β
-‐transducinrepeat
PI3Kinhibitors
A66
PI3Kinhibitor, p
110α
AS-‐605240
PI3Kinhibitor, p110
γ
AS-‐604850
PI3Kinhibitor, p110
α
/
γ
