Class I phosphoinositide3-‐kinases in immunity…
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ADDENDA: ABBREVIATIONSANDLISTOFPI3K INHIBITORS
Abbreviations
ABD
Adaptorbindingdomain
AIA
Adjuvant-‐inducedarthritis
Akt
ProteinkinaseB
ATG13
Autophagy-‐relatedprotein13
ATM Ataxia-‐telangiectasiamutatedprotein(ATM)
ATR
Ataxia-‐ andRad3-‐relatedprotein(ATR)
BAD
Bcl-‐2-‐associateddeathpromoter
BCAP
B-‐cell adaptor forPI3K
BCL6
Bcell lymphoma6transcriptionrepressor
BCR
Bcell receptor, antigenreceptorofBlymphocytes
BH
BCR-‐homologyGTPaseactivationdomain
Btk
Bruton’s tyrosinekinase
BTLA
B-‐andT-‐lymphocyteattenuator, CD272
CIA
Collagen-‐inducedarthritis
CNS
Central nervous system
CTLA-‐4 CytotoxicT-‐LymphocyteAntigen4, CD152
DNA-‐PKcs DNA-‐dependentproteinkinasecatalytic subunit
EAE
ExperimentalAutoimmuneEncephalomyelitis
Erk
Extracellular signal-‐regulatedkinase
FLS
Fibroblast-‐likesynoviocyte
FYVE
Fab1(yeast orthologueof PIKfyve), YOTB, Vac1(vesicle transport
protein), andEEA1domain
FOXO
forkheadtranscription factor/forkheadboxOtranscription factors
GAP
GTPaseactivating factors
GC
Germinal center
GEF
Guaninenucleotideexchange factors
Gproteins HeterotrimericGuaninenucleotide-‐bindingproteins
GPCR
Gprotein–coupledreceptor
GSK-‐3
Glycogensynthasekinase3
ICOS
Induciblecostimulator, CD278
ITAM ImmunoreceptorTyrosine-‐basedactivationmotif
Itk
Interleukin-‐2-‐inducibleT-‐cell tyrosinekinase
IKK
I
κ
Bkinase
HEAT
Huntington, ElongationFactor3, PR65/A, TORdomains
LAT
Linkerof activationofTcells
MAPK
Mitogenactivatedproteinkinase
MHC
MajorHistocompatibilityComplex
MOG
MyelinOligodendrocyteGlycoprotein
