Novel compounds containing1,3,4-‐oxadiazole…
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Table1.-‐
Antifungal activityof novel compounds synthesized.
Compound
-‐R -‐R
1
-‐R
2
Zoneof inhibition inmm
(MIC inμg/mL)
Aspergillusniger
NCCS1196
Candidaalbicans
NCCS2106
VIIa
H
CH
3
C
6
H
5
2.25(55)
1.75(52.5)
VIIb CH
3
CH
3
C
6
H
5
1.75(45)
1.25(52.5)
VIIc
OCH
3
CH
3
C
6
H
5
1.5(52.5)
1.5(52.5)
VIId OC
2
H
5
CH
3
C
6
H
5
1.5(47.5)
1.25(50)
VIIe
Cl
CH
3
C
6
H
5
1.75(40)
2(120)
VIIf
Br
CH
3
C
6
H
5
1.75(40)
1.75(42.5)
VIIg
H CH
3
CH
6
C
6
H
5
1.25(52.5)
1.25(50)
VIIh
H CH
3
ClC
6
H
4
2(37.5)
1.75(33.75)
VIIi
H CH
3
OCH
3
C
6
H
4
1.5(195)
1.5(>50)
VIIj
H CH
3
NO
2
C
6
H
4
1.75(41.25)
1.75(41.25)
IXa
H H
p
-‐tolyl
2.5(45)
2.25(45)
IXb
H H
p
-‐anisyl
2.25(47.5)
2(45)
IXc
H H
p
-‐fluorophenyl
3.5(35)
3(37.5)
IXd
H H
p
-‐chlorophenyl
3.25(37.5)
3.5(36.25)
IXe
H H
p
-‐bromophenyl
3.25(37.5)
3(37.5)
IXf
H H
p
-‐nitrophenyl
3.75(32.5)
3.25(36.25)
IXg
H H diethyl
2(47.5)
1.75(47.5)
IXh
H H di phenyl
2(47.5)
2(47.5)
IXi
H H morphonilyl
3.5(35)
3.25(35)
IXj
H H Piperizyinyl
3.25(37.5)
3(35)
IXk
H H
N
-‐methyl
piperizine
3.25(35)
3.25(32.5)
Table2.-‐
Antibacterial activityof novel compounds synthesized.
Compound
Zoneof inhibition inmm
(MIC inμg/mL)
Staphylococus
aureus
NCCS2079
BacillusCereus
NCCS2106
Escherichiacoli
NCCS2065
Pseudomanas
aeruginos
NCCS2200
VIIa
1.5(50)
1.25(52.5)
1.25(52.5)
1.75(45)
VIIb
1.5(50)
1.25(52.5)
1(55)
1.5(50)
VIIc
1(50)
1.25(50)
1(55)
1.25(52.5)
VIId
2(42.5)
1.5(47.5)
1(50)
1.75(47.5)
VIIe
2(31.25)
2.25(35)
1.5(47.5)
2(32.5)
VIIf
1.75(35)
2(35)
1.5(45)
1.25(47.5)
VIIg
1(55)
1.25(55)
1(60)
1.25(60)
VIIh
2(31.25)
2(36.25)
1.5(40)
1.75(32.5)
VIIi
1(50)
1.5(47.5)
1.5(45)
1.25(50)
VIIj
1.75(33.75)
2(35)
1.5(38.75)
1.75(41.25)
IXa
1.5(52.5)
1.75(57.5)
1.25(57.5)
1.5(60)
IXb
1.75(50)
1.5(52.5)
1.5(55)
1.25(57.5)
IXc
2.5(36.25)
2.75(38.75)
2.25(38.75)
2.5(38.75)
IXd
3(35)
2.5(38.75)
2.25(38.75)
2.75(36.25)
IXe
2.5(37.5)
2.75(38.75)
2(40)
2.25(37.5)
IXf
2.75(36.25)
2.5(38.75)
2.5(35)
2.5(35)
IXg
1.75(50)
2(52.5)
1.5(57.5)
5(57.5)
IXh
1.75(50)
1.75(50)
5(60)
1.5(55)
IXi
2.5(37.5)
3(35)
2.5(37.5)
2.75(35)
