201
Novel Compounds containing 1,3,4-‐oxadiazole and pyrazole-‐3-‐
oneNuclei –Synthesis and
invitro
Antimicrobial Evaluation
KrishnaNaik
1
, AluruRaghavendraGuruPrasad
2*
, Yadati Narasimha Spoorthy
1
,
Mokkapati Pariplavi
3
, LakshmanaRaoKrishnaRaoRavindranath
1
1
Sri Krishnadevaraya University, Anantapur, A.P., India.
2
ICFAI Foundation for Higher Education,
Hyderabad, A.P., India.
3
OsmaniaMedical College, OsmaniaUniversity, Hyderabad, A.P., India.
*e-‐mail:
An. Real Acad. Farm. Vol 80, Nº 1(2014), pág. 201-‐213
ABSTRACT
Newseriesof heterocycles containing1,3,4-‐oxadiazoleandpyrazole-‐3-‐onemoiety
have been synthesized and evaluated
in vitro
against
Staphylococus aureus
NCCS
2079,
Bacillus cereus
NCCS 2106,
Escherichia coli
NCCS 2065,
Pseudomanas
aeruginosa
NCCS 2200,
Aspergillus niger
NCCS 1196 and
Candida albicans
NCCS
2106. The compounds demonstrated moderate antimicrobial activity against
selected fungal andbacterial strains.
Keywords:
Synthesis; 1,3,4-‐Oxadiazoles; Pyrazole-‐3-‐ones;Antimicrobial activity.
RESUMEN
Nuevos compuestosque contienennúcleos 1,3,4-‐oxadiazol ypirazol-‐3-‐ona. Sintesis y
actividadantimicrobiana"invitro"
Nuevas series de compuestos heterocíclicos que contienen 1,3,4-‐oxadiazol y
pyrazol-‐3-‐ona han sido sintetizadas y evaluadas in-‐vitro contra
Staphylococus
aureus
NCCS 2079,
Bacillus cereus
NCCS 2106,
Escherichia coli
NCCS 2065,
Pseudomanas aeruginosa
NCCS 2200,
Aspergillus niger
NCCS 1196 y
Candida
albicans
NCCS 2106. Los compuestos demostraron actividad antimicrobiana
moderadacontraestirpes fúngicasybacterianas seleccionadas.
Palabrasclave:
Síntesis;1,3,4-‐Oxadiazol;Pyrazol-‐3-‐uno;Actividadantimicrobiana.
ARTÍCULO
