Envejecimiento cerebral normal y patológico …
539
109. Scheff, S. W.; Neltner, J. H.; Nelson, P. T. Is synaptic loss a unique hallmark of Alzheimer's
disease? Biochem Pharmacol.
9
(en prensa) (2014). doi: 10.1016/j.bcp.2013.12.028.
110. Lee, C. W.; Shih, Y. H.; Kuo, Y. M. Cerebrovascular pathology and amyloid plaque
formation in Alzheimer's disease. Curr Alzheimer Res
11
, 4-‐10 (2014).
111. Beason-‐Held, L. L.; Goh, J. O.; An, Y.; Kraut, M. A.; O'Brien, R. J.; Ferrucci, L.; Resnick, S. M.
Changes in brain function occur years before the onset of cognitive impairment. J Neurosci
13
, 18008-‐18014 (2013).
112. Wang, X.; Wang, W.; Li, L.; Perry, G.; Lee, H. G.; Zhu, X. Oxidative stress and mitochondrial
dysfunction in Alzheimer's disease. Biochim Biophys Acta. (en prensa) (2013) doi:
10.1016/j.bbadis.2013.10.015.
113. Jellinger, K. A.; Attems, J. Neuropathological approaches to cerebral aging and
neuroplasticity. Dialogues Clin Neurosci
15
, 29-‐43 (2013).
114. Lefort, R.; Pozueta, J.; Shelanski, M. Cross-‐linking of cell surface amyloid precursor
protein leads to increased β-‐amyloid peptide production in hippocampal
neurons:
implications for Alzheimer's disease. J Neurosci
32
, 10674-‐10685 (2012).
115. Shulman, J. M.; Chibnik, L. B.; Aubin, C.; Schneider, J. A.; Bennett, D.A.; De Jager, P. L.
Intermediate phenotypes identify divergent pathways to Alzheimer's disease. PLoS One
5(6),
e11244 (2010). doi: 10.1371/journal.pone.0011244.
116. Oikawa, N.; Kimura, N.; Yanagisawa, K. Alzheimer-‐type tau pathology in advanced aged
nonhuman primate brains harboring substantial amyloid deposition. Brain Res
1315
,
137-‐149 (2010).
117. Bell, K. F.; Ducatenzeiler, A.; Ribeiro-‐da-‐Silva, A.; Duff, K.; Bennett, D. A., Cuello, A. C. The
amyloid pathology progresses in a neurotransmitter-‐specific manner. Neurobiol Aging
27
,
1644-‐1657 (2006).
118. Arnold, S.E.; Han, L. Y.; Clark, C. M.; Grossman, M.; Trojanowski, J. Q. Quantitative
neurohistological features of frontotemporal degeneration. Neurobiol Aging
21
, 913-‐919
(2000).
119. Toledano, A.; Álvarez M. I. Lesion-‐induced vertebrate models of Alzheimer Dementia. En
Animal models of Dementia; Deyn, P.P.; Van Dam, D. (Eds). Humana Press; Amsterdam,
210; pp 295-‐345.
120. Toledano, A.; Álvarez M. I.; Toledano-‐Díaz,, A. Diversity and variability of the nicotine
effects on different brain cortical regions. Therapeutic and toxicologic implications. CNS
Agents Med Chem
10
, 180-‐206 (2010).
